Ji, Lulu https://orcid.org/0000-0001-8194-019X
Nai, Yaru
Chen, Zhiguo
Zhong, Yu
Zhu, Hengxuan
Huang, Yanyi
Zhang, Xiaoli
Wang, Yuexiao
Yang, Xiting
Wang, Qiongtao
Hu, Hanyang https://orcid.org/0000-0002-5867-3668
Wang, Lin
Funding for this research was provided by:
National Natural Sciences Foundation of China (Grant 82171681)
National Natural Sciences Foundation of China (L.W.)
National Natural Science Foundation of Hubei Province (Grant 2022CFB035)
National Natural Science Foundation of Hubei Province (Y. H.)
Article History
Received: 27 May 2025
Accepted: 28 October 2025
First Online: 15 December 2025
Acknowledgements
: We thank all the volunteers who agreed to participate in the present study and all those who helped us successfully complete the research.
: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
: This study was supported by grants from the National Natural Sciences Foundation of China (Grant 82171681, LW) and the National Natural Science Foundation of China (Grant 81901505, HH).
: The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.
: LJ, YN, HH and LW conceived and designed the experiments; LJ, XZ and ZC contributed to acquisition of the clinical data; LJ, YN, HZ, YH, XY, YW, YZ and QW performed experiments and analysed the data; LJ, YN, HH and LW wrote and edited the original draft and prepared the figures. All authors critically read and commented on the manuscript and approved the final version for submission. HH is the guarantor of this work.