Stevelink, Sharon A. M. https://orcid.org/0000-0002-7655-7986
Ledden, Sarah https://orcid.org/0000-0002-5121-7934
Bakolis, Ioannis https://orcid.org/0000-0002-4800-1630
Leal, Ray
Madan, Ira https://orcid.org/0000-0003-2200-7329
Hotopf, Matthew https://orcid.org/0000-0002-3980-4466
Fear, Nicola T. https://orcid.org/0000-0002-5792-2925
Lorentzen, Thomas https://orcid.org/0000-0001-9952-8929
Funding for this research was provided by:
National Institute for Health and Care Research (NIHR300592)
National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London
Article History
Received: 20 December 2024
Accepted: 7 May 2025
First Online: 30 May 2025
Declarations
:
: MH is principal investigator of RADAR-CNS consortium—a public private partnership in collaboration with five pharmaceutical companies—Janssen, Biogen, UCB, MSD and Lundbeck, outside of the submitted work. SAMS is an independent scientific member of the Industrial Injuries Advisory Council (IIAC). The other authors declare that they have not conflict of interest relevant to the content of this article. The funder had no contribution in the study design, data collection, analysis and interpretation of the data, manuscript writing and the decision to submit the paper for publications.
: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. All procedures involving patients were approved by the South Central—Oxford C Research Ethics Committee (ref 17/SC/0581, 22/SC/0400 and 23/SC/0257). Section 251 approval was provided by the NHS Health Research Authority Confidential Advisory Group (ref 17 CAG0055) as it was not deemed practical or feasible to obtain informed consent from all patients.