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Authors
Rozemeijer, Sander https://orcid.org/0000-0002-1185-4373
Dubois, Eric A. https://orcid.org/0000-0002-6727-8635
de Grooth, Harm-Jan https://orcid.org/0000-0002-7499-076X
den Uil, Corstiaan A. https://orcid.org/0000-0003-0635-2843
Rettig, Thijs C. D. https://orcid.org/0000-0001-5634-9672
Rijpstra, Tom A.
van den Bogaard, Bas https://orcid.org/0000-0002-6155-6403
van Zanten, Arthur R. H.
Bosman, Rob J.
Elbers, Paul W. G.
Girbes, Armand R. J.
Vlaar, Alexander P. J.
Twisk, Jos W. R. https://orcid.org/0000-0001-9617-1020
Christopher, Kenneth B.
Schober, Patrick
Oudemans-van Straaten, Heleen M. https://orcid.org/0000-0001-9328-6703
de Man, Angélique M. E. https://orcid.org/0000-0001-8738-8295
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Clinical Trials BETA
Clinical trials referenced in this document:
nct03509662 at ClinicalTrials.govDocuments that mention this clinical trial
Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial
https://doi.org/10.1007/s00134-026-08492-5
Early intravenous high-dose vitamin C in postcardiac arrest shock (VICEPAC): study protocol for a randomised, single-blind, open-label, multicentre, controlled trial
https://doi.org/10.1136/bmjopen-2024-087303
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Funding
Funding for this research was provided by:
ZonMw (848081001)
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Article History
Received: 20 March 2026
Accepted: 14 May 2026
First Online: 16 June 2026
Declarations
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: SR, HJdG, TR, AvZ, PE, AG, HOvS and AdM received funding for this trial from the Netherlands Organization of Health Research and Development. AdM received an honorarium for a lecture for Pascoe and travel expenses for the Critical Care Reviews Down Under in Melbourne. AdM and AvZ received recently a grant from the EU (MSCA-DN) for the BIO-MICRO project. AvZ received honoraria for advisory board meetings, lectures, research, and travel expenses from AOP Pharma, Abbott, Baxter, Cardinal Health, Danone-Nutricia, Dutch Medical Food, Fresenius Kabi, GE Healthcare, GSK, InBody, and Rousselot. The other authors declare that they have no potential conflicts of interest, any relevant financial activities outside the submitted work, or any other relationships or activities that readers could perceive to have influenced, or that give the appearance of potentially influencing what is written in the submitted work.
: The study was approved by the ethics committee at Amsterdam UMC, location VUmc (VU University Medical Centre Protocol Record METC-2018.120). The ethics committee approved starting study interventions before obtaining informed consent to avoid treatment delays. All substantial protocol amendments were submitted to the Central Committee on Research Involving Human Subjects and the Medical Ethics Committee of Amsterdam UMC, location VUmc. Approved amendments were communicated to the principal investigators of the participating hospitals.
