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Article History

Received: 21 November 2020

Accepted: 1 April 2021

First Online: 20 April 2021

Declarations

:

: Approved by Hospital for Special Surgery and the NewYork-Presbyterian Hospital/Weill Cornell Medical Center IRB. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.

: Not applicable.

: Informed consent was obtained from all individual participants included in the study.

: Disclosures, all unrelated to the current work: JL is a consultant for Mesentech, Radius Health, Kuros, and Terumo, BCT. JL is a consultant and Medical/Scienific Advisory Board Member at the ON Foundation. JL also receives research support from Radius Health, Merck and Novartis. GR is a consultant or serves on the Advisory Board or serves on the Data and Safety Monitoring Committee for the following: AbbVie, Actinium, Agios, Amphivena, Argenx, Array Biopharma, Astex, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Celgene, Celltrion, Daiichi Sankyo, Eisai, Epizyme, Glaxo SmithKline, Helsinn, Janssen, Jasper Therapeutics, Jazz, MEI Pharma (IDMC Chair), Novartis, Orsenix, Otsuka, Pfizer, Roche/Genentech, Sandoz, Takeda (IRC Chair), and Trovagene. GR also receives research support from Cellectis. PD serves on the Advisory Board for Celgene and Sanofi; PD also receives research funding from Janssen. EMS reports research funding from Novartis and Radius. The authors AK, AH, KP, KK, TP, DM, DH, DJM, KAK, and RSB declare that they have no conflict of interest.