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Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin

Crossref DOI link: https://doi.org/10.1007/s00204-023-03572-7

Published Online: 2023-09-04

Published Print: 2023-11

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ramirez-Hincapie, Sabina https://orcid.org/0000-0002-8795-7061
Birk, Barbara https://orcid.org/0000-0002-1208-8527
Ternes, Philipp https://orcid.org/0000-0003-0886-5474
Giri, Varun

Zickgraf, Franziska Maria https://orcid.org/0000-0003-4269-1316
Haake, Volker https://orcid.org/0000-0001-7124-6727
Herold, Michael https://orcid.org/0000-0001-7733-0196
Kamp, Hennicke https://orcid.org/0000-0002-1316-8756
Driemert, Peter https://orcid.org/0000-0001-5650-5380
Landsiedel, Robert https://orcid.org/0000-0003-3756-1904
Richling, Elke https://orcid.org/0000-0001-5746-8032
Funk-Weyer, Dorothee

van Ravenzwaay, Bennard https://orcid.org/0000-0002-4264-9217
Funding

Funding for this research was provided by:

Bundesministerium für Bildung und Forschung (161L0243A)

Horizon 2020 Framework Programme (681002)
License Information

Text and Data Mining valid from 2023-09-04

Version of Record valid from 2023-09-04
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Article History

Received: 30 May 2023

Accepted: 2 August 2023

First Online: 4 September 2023

Declarations

:

: The authors have no conflicts of interest to declare. BASF may use some of the presented technologies for product development in the future.

: The manuscript does not contain clinical studies or patient data.

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