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Structure–metabolism relationships of 4-pentenyl synthetic cannabinoid receptor agonists using in vitro human hepatocyte incubations and high-resolution mass spectrometry

Crossref DOI link: https://doi.org/10.1007/s00204-025-04080-6

Published Online: 2025-05-20

Published Print: 2025-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Baginski, Steven R. https://orcid.org/0000-0001-5615-1199
Lindbom, Karin

Valencia Crespo, Bryan

Bessa, Ghidaa

Rautio, Tobias https://orcid.org/0000-0002-0857-6261
Wu, Xiongyu https://orcid.org/0000-0001-6756-2276
Dahlén, Johan

Nisbet, Lorna A. https://orcid.org/0000-0002-8789-9113
McKenzie, Craig https://orcid.org/0000-0001-7244-5779
Gréen, Henrik https://orcid.org/0000-0002-8015-5728
Funding

Funding for this research was provided by:

Eurostars-2 (E! 113377)

Eurostars-3 (E! 2297)

Horizon 2020

VINNOVA (2019-03566)

Strategic Research Area in Forensic Sciences [Styrkeområdet forensiska vetenskaper], Linköping University

Leverhulme Trust (RC-2015-01)
License Information

Text and Data Mining valid from 2025-05-20

Version of Record valid from 2025-05-20
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Article History

Received: 9 November 2024

Accepted: 7 May 2025

First Online: 20 May 2025

Declarations

:

: Craig McKenzie is employed by Chiron AS, a producer and provider of NPS reference materials. The remaining authors declare that they have no conflict of interest.

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