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Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations

Crossref DOI link: https://doi.org/10.1007/s00204-025-04163-4

Published Online: 2025-10-31

Published Print: 2026-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Berardinelli, Diletta https://orcid.org/0009-0001-3005-5825
Taoussi, Omayema https://orcid.org/0009-0008-0633-2117
Ovat, Duygu Yeşim https://orcid.org/0000-0003-1310-0118
Pichini, Simona https://orcid.org/0000-0002-6347-0750
Pulver, Benedikt https://orcid.org/0000-0002-7772-2111
Auwärter, Volker https://orcid.org/0000-0002-1883-2804
Busardò, Francesco Paolo https://orcid.org/0000-0002-3082-4532
Basile, Giuseppe https://orcid.org/0000-0001-9602-4223
Laudadio, Emiliano https://orcid.org/0000-0002-8053-6539
Carlier, Jeremy https://orcid.org/0000-0003-3332-9518
Funding

Funding for this research was provided by:

Università Politecnica delle Marche
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Text and Data Mining valid from 2025-10-31

Version of Record valid from 2025-10-31
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Article History

Received: 20 June 2025

Accepted: 18 August 2025

First Online: 31 October 2025

Declarations

:

: The authors declare no competing interests.