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Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers

Crossref DOI link: https://doi.org/10.1007/s00210-022-02235-1

Published Online: 2022-04-08

Published Print: 2022-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Koo, Seok Hwee https://orcid.org/0000-0003-4556-2624
Soon, Gaik Hong

Pruvost, Alain https://orcid.org/0000-0002-7781-7735
Benech, Henri

Ang, Tiing Leong

Lee, Edmund Jon Deoon

Ang, Daphne Shih Wen
Funding

Funding for this research was provided by:

Changi General Hospital Research Grant (CHF2015.12-P)
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Article History

Received: 31 January 2022

Accepted: 21 March 2022

First Online: 8 April 2022

Declarations

:

: The study was approved by the SingHealth Centralized Institutional Review Board (CIRB Ref No. 2016/2079). The study was carried out in accordance with the Declaration of Helsinki and followed the International Conference on Harmonization Guidelines for Good Clinical Practice.

: Written informed consent was obtained from all participating volunteers prior to enrollment in the study.

: Not applicable

: The authors declare no competing interests.

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