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Authors
Martins, Italo Rossi Roseno
de Melo Medeiros, Millena
Vasconcelos, Luiz Henrique César
Silva, Maria da Conceição Correia
Queiroga, Fernando Ramos
Cavalcante-Silva, Luiz Henrique Agra
da Costa Nunes, Isabelle Karine
Lima, Lidia Moreira
da Silva, Patricia Mirella
Silva, Bagnólia Araújo da
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Funding
Funding for this research was provided by:
Conselho Nacional de Desenvolvimento Científico e Tecnológico (476692/2012-1)
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Article History
Received: 3 November 2023
Accepted: 11 December 2023
First Online: 18 December 2023
Declarations
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: All experiments were previously approved by the Ethics Committee on Animal Use of UFPB (protocol CEUA/UFPB 0610/11). The procedures adopted to reduce the pain and suffering of animals were carried out in accordance with the Ethical guidelines for investigation of experimental pain in conscious animals (Zimmermann ) and the Guidelines for the ethical use of animals in applied etiology studies (Sherwin et al. ). Also, the authors followed the ARRIVE Guidelines for Reporting Animal Research (Kilkenny et al. ). To adapting to the 3Rs Principle, measures were adopted to choose the appropriate animal model and plan the number of animals and their maximum reuse for different experimental protocols. Furthermore, other measures adopted included: Adoption of adequate accommodation, environment, food, and environmental control according to their biology; and carrying out appropriate management for the species, which was carried out only by people properly trained for this purpose.
: The authors declare no competing interests.
