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Article History

Received: 19 June 2025

Accepted: 6 October 2025

First Online: 8 November 2025

Declarations

:

: The animal studies were performed after receiving approval from the Damietta Faculty of Medicine IRB, Al Azhar University, Damietta, Egypt (DMF-IRB Approval number: 00012367–24-05–008). Animal models are among the most crucial in vivo models concerning basic parameters like drug efficiency, safety, and toxicological studies, as these pre-clinical data are essential before translating into humans. The use and handling of animals in our study complied with ARRIVE guidelines for animal experiments.

: All the authors approved the participation.

: All the authors approved the publication of the manuscript.

: The authors declare no competing interests.