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Authors
Silva, Guilherme Eduardo Rocha
Padovezi, Ana Clara Emilio
Barzotti, Renan José
Sampaio, Larissa Victorino
de Freitas, Rayara Nogueira
Furuse, Cristiane
Fakhouri, Walid D.
Lima, Rafael Rodrigues
Matsumoto, Mariza Akemi
Chaves-Neto, Antonio Hernandes
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Funding
Funding for this research was provided by:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (001)
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Article History
Received: 16 September 2025
Accepted: 16 October 2025
First Online: 29 October 2025
Declarations
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: The study was approved by the Ethics Committee on Animal Use (CEUA) of the São Paulo State University (Unesp), School of Dentistry, Araçatuba, São Paulo, Brazil (Authorization Protocol No. 0251–2021; Certificate No. 264–2024). The experiments were conducted in accordance with the Brazilian Guidelines of the National Council for the Control of Animal Experimentation (CONCEA— ) and the European Directive 2010/63/EU. All procedures followed the ARRIVE guidelines. Anesthesia was performed with ketamine, and all efforts were made to minimize animal suffering.
: For this type of study, formal consent is not required.
: Not applicable.
: Not applicable.
: Not applicable.
: The authors declare no competing interests.
