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Nose to brain delivery of dapoxetine-loaded PLGA nanoparticle for treatment of premature ejaculation distress in normal and diabetic rats with in silico targeting brain FOX and serotonin proteins

Crossref DOI link: https://doi.org/10.1007/s00210-025-04876-4

Published Online: 2025-12-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

El-Ela, Fatma I. Abo

Salem, Heba F.

Nafady, Mohamed M.

Kharshoum, Rasha M.

Farouk, Hanan O.
Funding

Funding for this research was provided by:

Beni Suef University
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Text and Data Mining valid from 2025-12-23

Version of Record valid from 2025-12-23
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Article History

Received: 26 June 2025

Accepted: 29 November 2025

First Online: 23 December 2025

Declarations

:

: All animal handling, weighting, and treatment were carried out according to the ethical animal’s treatment of the Institutional Animal Care and Use Committee (IACUC) of Beni-Suef University.

: All authors agree about this study’s publishing.

: The authors declare no competing interests.

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