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Article History

Received: 12 June 2025

Accepted: 7 July 2025

First Online: 29 August 2025

Declarations

:

: The trial was preregistered (German clinical trials database: DRKS00029993, study protocol can be accessed via DRKS.de; date of registration: 2022–08-10). All experimental procedures were approved by the local ethics committee of the University of Heidelberg. The clinical trial was designed and conducted in compliance with Good Clinical Practices (ICH-GCP) and the Declaration of Helsinki.The trial consisted of two on-site visits, which were scheduled on two consecutive days, as screening visit and assessment visit. In the screening visit, participants underwent an assessment of individual characteristics and informed consent was obtained. To ensure the anonymity of all participants, subjects were identified solely by means of their pseudonymized individual identification code during the study. Individuals who did not consent to circulate their pseudonymised data were not included into the study. The data obtained in the course of the study was treated in accordance to the EU General Data Protection Regulation (GDPR) and national regulatory requirements (e.g. Federal Data Protection Act).

: All participants provided written informed consent before enrollment in the study. They were informed about the purpose of the research, their right to withdraw at any time without consequences, and the measures taken to protect their confidentiality.

: Participants were informed that anonymized data and results would be published in scientific journals and other academic platforms. They provided explicit consent for the publication of their data in an aggregated and de-identified manner.

: The authors report no biomedical financial interests or potential conflicts of interest.