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Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD

Crossref DOI link: https://doi.org/10.1007/s00213-025-06891-y

Published Online: 2025-09-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Fujita, Sho

Fuchikami, Manabu https://orcid.org/0000-0002-7759-6813
Fujita, Satoshi

Miyagi, Tatsuhiro

Okada, Satoshi

Omura, Jun

Morinobu, Shigeru
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science (JP25K19060)
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Article History

Received: 18 June 2025

Accepted: 12 August 2025

First Online: 13 September 2025

Declarations

:

: All animal procedures were conducted in accordance with the Hiroshima University Animal Care and Use Committee Guiding Principles on Animal Experimentation in Research Facilities for Laboratory Animal Science (permission number from the committee was # A24-36–2), and in accordance with the Guidelines for Proper Conduct of Animal Experiments of the Science Council of Japan.

: Not applicable.

: Not applicable.

: The authors have no competing interests to declare that are relevant to the content of this article.

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