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Authors
Wiedemann, Katja R.
Peter Ventura, Alejandra
Gerbig, Stefanie
Roderfeld, Martin
Quack, Thomas
Grevelding, Christoph G.
Roeb, Elke
Spengler, Bernhard
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Funding
Funding for this research was provided by:
Hessisches Ministerium für Wissenschaft und Kunst (LOEWE Center DRUID)
Deutsche Forschungsgemeinschaft (INST 162/500-1 FUGG)
Deutsche Forschungsgemeinschaft (RO3714/4-1)
Deutsche Forschungsgemeinschaft (Sp314/13-1)
Justus-Liebig-Universität Gießen
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Article History
Received: 14 October 2021
Revised: 18 January 2022
Accepted: 3 March 2022
First Online: 23 March 2022
Declarations
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: To keep the <i>S. mansoni</i> life cycle, <i>Biomphalaria glabrata</i> snails served as intermediate hosts and Syrian hamsters (<i>Mesocricetus auratus</i>) as final hosts. The hamster model has been established because it is more permissive for schistosome infection compared to the mouse model, which requires more animals (reduction principle of the 3Rs). Both snails and hamsters were bred in-house (Biomedical Research Center Seltersberg, Giessen, Germany). All animal experiments were conducted in accordance with the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (ETS No 123; revised Appendix A), and they were additionally approved by the Regional Council (Regierungspraesidium) Giessen (V54-19 c 20/15 c GI 18/10).
: B.S. and C.G.G. are consultants of TransMIT GmbH, Giessen, Germany. The other authors declare to have no conflicts of interest.
