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Development of a candidate reference method for the simultaneous quantification of betaine, choline and trimethylamine N-oxide in serum samples by two-dimensional liquid chromatography and isotope dilution tandem mass spectrometry

Crossref DOI link: https://doi.org/10.1007/s00216-025-05914-z

Published Online: 2025-05-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Pineda-Cevallos, Daniela

Castañón Apilánez, María

Cancio-López, Elena

Prieto García, Belén

García Alonso, J. Ignacio

Rodríguez-González, Pablo
Funding

Funding for this research was provided by:

Ministerio de Ciencia, Innovación y Universidades (MCIU-22-PID2021-125795NB-I00)

Gobierno del Principado de Asturias (BP22-061)

Instituto de Salud Carlos III (RI-CORSICTUS (RD21/0006/0022))

Universidad de Oviedo
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Article History

Received: 19 March 2025

Revised: 2 May 2025

Accepted: 6 May 2025

First Online: 23 May 2025

Declarations

:

: Full ethical approval was obtained from the Clinical Research Ethics Committee (Code 102/13) of the Principality of Asturias (Oviedo, Spain).

: The authors declare no competing interests.

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