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Comparative evaluation of phenyl isothiocyanate derivatization and “dilute-and-shoot” methods for HPLC–MS/MS-based targeted metabolomics analysis of amine-containing metabolites in plasma samples

Crossref DOI link: https://doi.org/10.1007/s00216-025-06079-5

Published Online: 2025-08-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xu, Kangkang https://orcid.org/0000-0002-5163-5925
Aigensberger, Markus https://orcid.org/0009-0000-2516-9097
Berthiller, Franz https://orcid.org/0000-0001-5883-2879
Schwartz-Zimmermann, Heidi E. https://orcid.org/0000-0003-2897-7991
Funding

Funding for this research was provided by:

Christian Doppler Forschungsgesellschaft (CDL-LiveGut)

University of Natural Resources and Life Sciences Vienna
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Text and Data Mining valid from 2025-08-30

Version of Record valid from 2025-08-30
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Article History

Received: 2 June 2025

Revised: 10 August 2025

Accepted: 13 August 2025

First Online: 30 August 2025

Declarations

:

: The methods and protocols followed in this experiment were approved by the institutional ethics and animal welfare committee of the University of Veterinary Medicine Vienna and the Austrian national authority according to the law for animal experiments 2012—Tierversuchsgesetz (BMWFW 2022-0855.741).

: The authors declare no competing interests.

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