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Authors
Ma, Canchen
Shen, Ziyuan
Tian, Jing
Schooneveldt, Yvette L.
Giles, Corey
Cicuttini, Flavia
Jones, Graeme
Meikle, Peter J.
Pan, Feng https://orcid.org/0000-0002-3403-0094
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Funding
Funding for this research was provided by:
Australian Heart Foundation Postdoctoral Fellowship (102614)
NHMRC Investigator Grants –Leadership Level 2 (1194829)
NHMRC of Australia Practitioner Fellowship (1117037)
H2020 Leadership in Enabling and Industrial Technologies (2009965)
NHMRC Early Career Fellowship (1157535)
University of Tasmania
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Article History
Received: 27 January 2025
Accepted: 28 May 2025
First Online: 25 June 2025
Declarations
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: Canchen Ma, Ziyuan Shen, Jing Tian, Yvette L. Schooneveldt, Corey Giles, Flavia Cicuttini, Graeme Jones, Peter J. Meikle, and Feng Pan declare that they have no conflict of interest.
: This study was approved by the Southern Tasmanian Health and Medical Human Research Ethics Committee (Ref. no: H0006488), and written informed consent was obtained from all participants.
: This study explores the causal relationship between lipid metabolism and changes in bone mineral density (BMD) and fracture risk through integrated two-sample Mendelian randomization (MR) and observational analysis. The two-sample MR analysis uncovers causal relationships between lipid classes and species with BMD and fractures. Validation in an independent cohort confirms associations for specific lipid species with hip BMD change and fracture risk over an 8-year period. These findings suggest lipid metabolism influences bone remodeling and fracture risk, highlighting the potential for targeted interventions and risk assessment in fracture prevention.
