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Article History

Received: 4 April 2018

Accepted: 31 May 2018

First Online: 15 June 2018

Compliance with ethical standards

: The protocol was approved by the institutional review board of Seoul National University Hospital (SNUH). The studies were conducted in accordance with the Declaration of Helsinki and International Conference on Harmonization guidelines. Written informed consents were obtained prior to enrolment in the studies.

: The authors Seong Bok Jang and Hae Mi Byun are employees of Yuhan Co. Ltd. The first author (Eunwoo Kim) received a scholarship from the BK21-plus education program provided by the National Research Foundation of Korea. Sojeong Yi is currently employed by the U.S. Food and Drug Administration. Her contribution to the manuscript was based on her prior employment, and the current manuscript does not reflect any position of neither the U.S. Food and Drug Administration nor the US government. The authors have no other potential conflicts of interest to disclose regarding the content of this article.