Article History
Received: 7 August 2018
Accepted: 14 September 2018
First Online: 4 October 2018
Compliance with ethical standards
:
: Actelion Pharmaceuticals Ltd., the predecessor of Idorsia Pharmaceuticals Ltd., provided funding for this clinical study, as owner of ACT-541468. At the time of the study conduct or reporting, M.-L.B., M.U., and J.D. were full-time employees of Actelion Pharmaceuticals Ltd. They are now full-time employees of Idorsia Pharmaceuticals Ltd., the current owner of ACT-541468. A.A. was an employee of Clinical Research Services Kiel GmbH. There are no other relationships or activities that could appear to have influenced the submitted work. Clinical Research Services Kiel GmbH received financial compensation for the clinical conduct.
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
: Informed consent was obtained from all individual participants included in the study.