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Authors
Mugikura, Shunji https://orcid.org/0000-0002-9138-610X
Mori, Naoko
Satake, Megumi
Chiba, Ippei
Taira, Makiko
Koyama, Takuya
Onuma, Tomomi
Saito, Tomo
Takase, Masato
N Motoike, Ikuko
Hidaka, Takanori
Otsuki, Akihito
Orui, Masatsugu
Obara, Taku
Nagami, Fuji
Nakaya, Naoki
Ogishima, Soichi
Kumada, Kazuki
Katsuoka, Fumiki
Koshiba, Seizo
Taki, Yasuyuki
Shimizu, Ritsuko
Kuriyama, Shinichi
Ohneda, Kinuko
Izumi, Yoko
Fuse, Nobuo
Hozawa, Atsushi
Kinoshita, Kengo
Yamamoto, Masayuki
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Funding
Funding for this research was provided by:
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
the Reconstruction Agency; the Ministry of Education, Culture, Sports, Science and Technology (MEXT); and the Japan Agency for Medical Research and Development (JP21km0105001, JP21km0105002, JP23dm0307003h0006, JP24tm0524003h0002)
JSPS KAKENHI (24K06543, 25K10609)
JSPS KAKENHI (24K06543, 25K10609)
Medical Research and Development (JP 25tm0524003h0003)
Medical Research and Development (JP23dm0307003h0006)
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Article History
Received: 14 March 2026
Accepted: 28 September 2026
First Online: 9 October 2026
Declarations
Ethics approval and consent to participate: This study was approved by an institutional ethics committee and was conducted. All participants provided written informed consent prior to participation.
Competing interests: The authors declare no competing interests.
