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Co-evolution of alpha-helical transmembrane protein residues: large-scale variant profiling and complete mutational landscape of 2277 known PDB entries representing 504 unique human protein sequences

Crossref DOI link: https://doi.org/10.1007/s00239-025-10262-8

Published Online: 2025-09-24

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Karagöl, Taner https://orcid.org/0009-0005-1011-7661
Karagöl, Alper https://orcid.org/0009-0001-7864-0732
Zhang, Shuguang https://orcid.org/0000-0002-3856-3752
Funding

Funding for this research was provided by:

Massachusetts Institute of Technology
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Text and Data Mining valid from 2025-09-24

Version of Record valid from 2025-09-24
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Article History

Received: 17 October 2024

Accepted: 5 August 2025

First Online: 24 September 2025

Declarations

:

: The authors declare no competing interests.

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