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Article History

Received: 11 February 2025

Accepted: 23 October 2025

First Online: 17 November 2025

Declarations

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: No conflicts of interest to declare. During the final rounds of the completion of this contribution, the need has emerged for downstream expert-level analyses of identified in this contribution 25 transcription factors that are significantly differentially enriched in binding to human brain development regulatory regions (BDRRs) vis-à-vis chimpanzee BDRRs. Similarly, the expert-level follow-up analyses appear necessary of the neuroanatomical and structural–functional features, as well as developmental timelines of identified in this contribution 202 human brain regions in which the increased expression of these 25 transcription factors was significantly enriched. To accomplish these tasks, the Artificial Intelligence (AI) Large Language Model (LLM) was employed. These analyses and reports were conceived, prompted, and developed by the author using Google’s Gemini (version 1.5 Pro) in September, 2025 (Google. (2025). Gemini (Version 1.5 Pro) [Large language model]. . Outputs was reviewed, analyzed, edited, and refined by the author, who are solely responsible for the content.

: Not applicable.

: Not applicable.