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Article History

Received: 7 November 2024

Revised: 17 March 2025

Accepted: 18 March 2025

First Online: 1 April 2025

Declarations

:

: FE: Felix Eckstein is a CEO/CMO and co-owner of Chondrometrics GmbH; he has provided consulting services to Merck KGaA, Kolon-Tissuegene (KTG), Servier, Galapagos, Novartis, 4P Pharma, Formation Bio, and Peptinov outside the submitted work. He and Chondrometrics have received grants from public and private sources (list upon request). AM: Ali Mobasheri has no conflicts or declare in connection with this manuscript. MB: Mikael Boesen is a shareholder of Image Analysis Group (IAG) and member of the scientific advisory board of Image Analysis Group and Chondrometrics. He has provided consulting services to Novartis, Eli Lilly, Philips, Siemens, and Esaote outside of the current work.

: Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for them. The content of this work has not been contingent upon approval from the study sponsor. ChatGPT 4.o was used to edit and proof-read parts of the manuscript, and to verify and specify terminology and definitions.