Wang, Yan-Ran
Baratto, Lucia
Hawk, K. Elizabeth
Theruvath, Ashok J.
Pribnow, Allison
Thakor, Avnesh S.
Gatidis, Sergios
Lu, Rong
Gummidipundi, Santosh E.
Garcia-Diaz, Jordi
Rubin, Daniel
Daldrup-Link, Heike E. http://orcid.org/0000-0002-4929-819X
Funding for this research was provided by:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD081123A)
the Andrew McDonough B+ Foundation
Article History
Received: 26 October 2020
Accepted: 10 January 2021
First Online: 1 February 2021
Declarations
:
: The authors declare no conflict of interest.
: Research PET/MR imaging studies have been approved by the Institutional Review Board at Stanford University and the University of Tübingen. All patients provided written informed consent to participate in a research PET/MR study and the results of this research will be published.
: Using a cohort study of 23 clinical whole-body <sup>18</sup>F-FDG PET/MRI subjects, we demonstrated that the AI-reconstructed ultra-low-dose <sup>18</sup>F-FDG PET images resemble high similarity with standard-dose <sup>18</sup>F-FDG PET images, based on both quantitative and qualitative clinical evaluations. The proposed PET reconstruction model also generalizes in an independent cohort study of 11 clinical whole-body <sup>18</sup>F-FDG PET/MRI subjects.
: We anticipate that our proposed model will enable a new generation of imaging exams for children that can be widely applied to interrogate health and disease without the risk of secondary cancer development later in life.