Delva, Aline
Koole, Michel
Serdons, Kim
Bormans, Guy
Liu, Longbin
Bard, Jonathan
Khetarpal, Vinod
Dominguez, Celia
Munoz-Sanjuan, Ignacio
Wood, Andrew
Skinbjerg, Mette
Wang, Yuchuan
Vandenberghe, Wim
Van Laere, Koen http://orcid.org/0000-0001-5200-7245
Funding for this research was provided by:
CHDI Foundation
Fund for Scientific Research Flanders
Article History
Received: 8 March 2022
Accepted: 12 August 2022
First Online: 24 August 2022
Declarations
:
: All procedures were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study has been approved by the institutional review board (University hospitals and KU Leuven Ethics Committee) and performed in accordance with the World Medical Association Declaration of Helsinki. Written informed consent was obtained from all the participants before study inclusion.
: AD is a PhD fellow of the Fund for Scientific Research Flanders (FWO). KVL and WV are Senior Clinical Investigators of the FWO. MK has no financial interests. JB, LL, AW, VK, YW, MS, CD, and IM-S are employed by CHDI Management, Inc. as advisors to CHDI Foundation, Inc. The radioligands have been provided by CHDI, USA, and the human imaging study has been performed in Leuven, Belgium, under contract between CHDI and KU Leuven. The following granted patent is related to this work: Probes for Imaging Huntingtin Proteins, International Publication Number WO 2016/033445 Al (published on 3 March 2016 with filing number #PCT/US2015/047407) for [<sup>11</sup>C]CHDI-180R, and WO 2017/040336 A1 (published on 9 March 2017 with filing number #PCT/US2016/049112) for [<sup>11</sup>C]CHDI-626.