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Article History

Received: 11 July 2023

Accepted: 4 February 2024

First Online: 17 February 2024

Declarations

:

: The study protocol as well as PET data analyses were approved by the local ethics committee of LMU Munich (application numbers 17–569 and 19–022). All participants provided written informed consent for PET imaging. Patients from Munich are part of the observational study registered at the German Clinical Trials Register (DRKS00016920). The study was carried out according to the principles of the Helsinki Declaration.

: Christian Ferschmann: noneKonstantin Messerschmidt: reader consultant honorarium from Life Molecular Imaging GmbH, 13353 Berlin, GermanyJohannes Gnörich: reader honorarium from Life Molecular Imaging GmbH, 13353 Berlin, GermanyHenryk Barthel: reader consultant honorarium from Life Molecular Imaging GmbH, 13353 Berlin, GermanyKen Marek: noneCarla Palleis: noneSabrina Katzdobler: noneAnna Stockbauer: noneUrban Fietzek: noneAnika Finze: noneGloria Biechele: noneLeonie Beyer: noneFlorian Eckenweber: noneStephan Wall: noneDorothee Saur: noneMatthias L. Schroeter: noneJost-Julian Rumpf: noneMichael Rullmann: noneAndreas Schildan: noneMarianne Patt: noneAndrew Stephens: employee of Life Molecular ImagingJoseph Classen: nonePeter Bartenstein: noneJohn Seibyl: noneNicolai Franzmeier: noneJohannes Levin: reports speaker fees from Bayer Vital, Biogen, EISAI, TEVA and Roche, consulting fees from Axon Neuroscience and Biogen, author fees from Thieme medical publishers and W. Kohlhammer GmbH medical publishers and is inventor in a patent “Oral Phenylbutyrate for Treatment of Human 4-Repeat Tauopathies” (EP 23 156 122.6) filed by LMU Munich. In addition, he reports compensation for serving as chief medical officer for MODAG GmbH, is beneficiary of the phantom share program of MODAG GmbH and is inventor in a patent “Pharmaceutical Composition and Methods of Use” (EP 22 159 408.8) filed by MODAG GmbH, all activities outside the submitted workGünter U. Höglinger: none related to this workOsama Sabri: received research support from Life Molecular ImagingMatthias Brendel: received speaker honoraria from GE healthcare, Roche and Life Molecular Imaging (LMI) and is an advisor of LMIMaximilian Scheifele: reader honorarium from Life Molecular Imaging GmbH, 13353 Berlin, Germany