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Authors
Matsuoka, Kiwamu https://orcid.org/0000-0003-3263-0958
Takado, Yuhei https://orcid.org/0000-0001-7484-8424
Kimura, Yasuyuki https://orcid.org/0000-0002-7927-9483
Kitamura, Akihiko
Kitamura, Hitomi
Kanda, Mayuka
Takada, Michihiro
Ono, Maiko https://orcid.org/0000-0003-2239-1754
Tatebe, Harutsugu
Endo, Hironobu
Kurose, Shin
Takahata, Keisuke
Ikoma, Yoko
Ichihashi, Masanori
Oya, Masaki
Hirata, Kosei
Matsumoto, Hideki
Orihara, Asumi
Kokubo, Naomi
Kataoka, Yuko
Zhang, Hong
Tagai, Kenji
Seki, Chie
Shinotoh, Hitoshi
Kikuchi, Tatsuya
Ichise, Masanori
Shimizu, Hiroshi
Kakita, Akiyoshi
Kawamura, Kazunori
Zhang, Ming-Rong
Shimada, Hitoshi
Nagao, Kenji
Tokuda, Takahiko
Higuchi, Makoto
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Funding
Funding for this research was provided by:
Japan Science and Technology Agency (JP22dk0207063, JP19dm0207072, JP22dk0207055, JP21zf0127004, JP24zf0127012)
Ajinomoto Co., Inc. (Ajinomoto Co., Inc.)
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Article History
Received: 2 July 2025
Accepted: 18 August 2025
First Online: 6 September 2025
Declarations
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: This study was approved by the Institutional Review Board of the NIRS and Ajinomoto Co., Inc. Written informed consent was obtained from all patients and their spouses or other close family members. The study was registered with the UMIN Clinical Trials Registry (UMIN-CTR; number 000043458).
: Informed consent was obtained from all individual participants included in the study.
: H.S. (Hitoshi Shimada), M.-R.Z., and M.H. hold patents on compounds related to the present report (JP5422782 / EP 12 884 742.3 / CA2894994 / HK1208672). A.K. (Akihiko Kitamura), H.K., M.K., M.T., and K.N.are employed by Ajinomoto Co. Inc. The remaining authors conducted research funded by Ajinomoto Co.Inc. The authors declare that they have no other competing interests.
: Not commissioned; externally peer-reviewed.
