Khaing, Phyo H.
MacAskill, Mark G.
Xiao, Jianfei
Liu, Shichao
Gu, Zhuqin
Sun, Xiaohiu
Xu, Tao
Koglin, Norman
Stephens, Andrew W.
Newby, David E.
Guan, Yihui
McErlain, Holly
Sutherland, Andrew
Tamagnan, Gilles D.
Xie, Fang
Tavares, Adriana Alexandre S. https://orcid.org/0000-0001-7505-9144
Funding for this research was provided by:
MRC (MR/W029464/1)
British Heart Foundation (RG/16/10/32375)
British Heart Foundation (RG/F/22/110093)
British Heart Foundation (CH/09/002)
Chan Zuckerberg Initiative (DAF2021-225273)
Article History
Received: 11 November 2025
Accepted: 11 December 2025
First Online: 10 January 2026
Declarations
:
: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Huashan Hospital, China.
: Informed consent was obtained from all individual participants included in the study.
: The authors declare a patent covering the development of LW223 (WO2019243616). Author Fang Xie is an editor in this journal.