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First Online: 13 June 2017

Compliance with ethical standards

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: The study was partially supported by the following Grants from the National Institutes of Health: R01DK088925, R56DK090350, R01EB001981, R01EB017197, and TL1TR00098. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

: The authors Kang Wang, Paul Manning, Nikolaus Szeverenyi, Tanya Wolfson, Gavin Hamilton, and Florin Vaida have nothing to disclose. The author Michael S. Middleton discloses the following: Consultant, Allergan, Inc. Institutional research contract, Bayer AG Institutional research contract, Sanofi-Aventis Group Institutional research contract, Isis Pharmaceuticals, Inc. Institutional research contract, Johnson & Johnson Institutional research contract, Synageva BioPharma Corporation Institutional research contract, Takeda Pharmaceutical Company Limited Stockholder, General Electric Company Stockholder, Pfizer Inc. Institutional research contract, and Pfizer Inc. The author Meng Yin discloses the following: intellectual property rights and financial interest in MRE technology. The author Kevin Glaser discloses the following: intellectual property rights in MRE technology and Stockholder in Resoundant Inc. The author Richard Ehman discloses the following: CEO, Resoundant Inc. Stockholder, Resoundant Inc. Research Grant, and Resoundant Inc. The author Claude Sirlin discloses the following: Research Grant, General Electric Company Research Grant, Siemens AG Research Grant, and Guerbet SA.

: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

: Informed consent was obtained from all individual participants included in the study.