Lee, Jeong-Hoon http://orcid.org/0000-0002-0315-2080
Lee, Joon Hyeok http://orcid.org/0000-0003-3547-7434
Lim, Young-Suk http://orcid.org/0000-0002-1544-577X
Yeon, Jong Eun http://orcid.org/0000-0002-0510-7371
Song, Tae-Jin http://orcid.org/0000-0001-9278-812X
Yu, Su Jong http://orcid.org/0000-0001-8888-7977
Gwak, Geum-Youn http://orcid.org/0000-0002-6453-3450
Kim, Kang Mo http://orcid.org/0000-0002-3180-3178
Kim, Yoon Jun http://orcid.org/0000-0001-9141-7773
Lee, Jae Won http://orcid.org/0000-0002-3718-2704
Yoon, Jung-Hwan http://orcid.org/0000-0002-9128-3610
Article History
Received: 19 February 2018
Accepted: 17 September 2018
First Online: 19 September 2018
Compliance with ethical standards
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: These authors disclose the following: Dr. Joon Hyeok Lee reports receiving grants from GREEN CROSS CELL Corp., Bukwang Pharmaceuticals, Pfizer, JW Creagene, and GlaxoSmithKline, and lecture fees from Bayer Pharmaceuticals, Gilead Science, Bukwang Pharmaceuticals, and GlaxoSmithKline, and serving as an advisory board member of Gilead Science and Bristol-Myers Squibb; Dr. Jung-Hwan Yoon, research grants from AstraZeneca and Bayer HealthCare Pharmaceuticals; Dr. Young-Suk Lim, research grants from Bayer HealthCare Pharmaceuticals, Gilead Science, and Bayer HealthCare Pharmaceuticals; Dr. Jong Eun Yeon, research grant from Yuhan Pharmaceuticals, and Jeil Pharmaceuticals, and serving as an advisory board member of Bayer Korea; Dr. Yoon Jun Kim, research grants from Bristol-Myers Squibb, Roche, JW Creagene, Bukwang Pharmaceuticals, Handok Pharmaceuticals, Hanmi Pharmaceuticals, Yuhan Pharmaceuticals, Samjin Pharmaceuticals, and Pharmaking, and lecture fees from Bayer HealthCare Pharmaceuticals, Gilead Science, Merck Sharp & Dohme (MSD) Korea, Yuhan Pharmaceuticals, Samil Pharmaceuticals, CJ Pharmaceuticals, Bukwang Pharmaceuticals, and Handok Pharmaceuticals; Dr. Kang Mo Kim, research grants from AstraZeneca, Yuhan Pharmaceuticals, and Il-dong Pharmaceuticals, lecture fees from Bayer HealthCare Pharmaceuticals, MSD, and GlaxoSmithKline, and consulting fee from Bayer HealthCare Pharmaceuticals; Dr. Geum-Youn Gwak, lecture fees from Bristol-Myers Squibb, JW Creagene, Handok Pharmaceuticals and MSD Korea; and Dr. Su Jong Yu, lecture fee from Bayer HealthCare Pharmaceuticals. No other potential conflict of interest relevant to this article was reported. Dr. Jeong-Hoon Lee, Dr. Tae-Jin Song, and Dr. Jae Won Lee report no conflict of interest.
: ClinicalTrials.gov identifier: NCT01890291. The study protocol was approved by the institutional review board at each participating center. All methods and procedures associated with this study were conducted in accordance with Good Clinical Practice guidelines and conformed ethically with the principles of the Declaration of Helsinki and local law.
: All included patients provided written informed consent.