Funding for this research was provided by:
Natural Science Foundation of Guangdong Province (2018A030313667, 2016A030310153, 2015A030310236, 2017A030310362)
Guangzhou Science and Technology Program key projects (201605030003)
National Natural Science Foundation of China (81602365)
Sun Yat-Sen University 5010 Plan (2010004)
General Research Fund from the Research Grant Council, Hong Kong (1711484, 17121616)
Theme-based Research from the Research Grant Council, Hong Kong (T12-401/13-R)
Direct Grant for Research, the Chinese University of Hong Kong (2016.095)
Text and Data Mining valid from 2018-10-25
Received: 2 April 2018
Accepted: 19 October 2018
First Online: 25 October 2018
Compliance with ethical standards
: The authors declare that they have no conflict of interest.
: All procedures involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (Approval no. 2012-349). Informed consent was obtained from all participants prior to enrollment in the study.