Text and Data Mining valid from 2018-10-31
Received: 1 February 2018
Accepted: 25 October 2018
First Online: 31 October 2018
Compliance with ethical standards
: All authors are employees of, and own stock or stock option in Celldex Therapeutics, Inc.
: and ethical standards and animal sources.
: Animals were sourced from IACUC-approved commercial sources. Murine xenograft studies (animal source: Taconic Biosciences) were approved by the Celldex IACUC of Hampton, NJ (AUP CDX-002) or the Celldex IACUC of Needham, MA (AUP 08-2017). Animal care followed the Guide for the Care and Use of Laboratory Animals: Eighth Edition (National Research Council. 2011. Washington, DC: The National Academies Press). The pilot primate study (animal source: Charles River Laboratories) was approved by the Charles River Laboratories IACUC of Shrewsbury, MA (AUP 20097548). Those animals were handled according to Guide for the Care and Use of Laboratory Animals: Eighth Edition and AAALAC rules (Association for Assessment and Accreditation of Laboratory Animal Care International). The primate toxicology study (animal source: Kunming Biomed International LTD) was approved by the Citoxlab IACUC of Montreal, QC (AUP 1016–3273). Those animals were handled according to The Canadian Council on Animal Care and AAALAC rules.
: Cell line authentication.
: Cell lines were sourced directly from vendors that provide authentication. CHO and EJ138 cells were purchased from Millipore-Sigma, HEK-293 cells were purchased from InvivoGen, NFkB luciferase reporter HEK293 stable cell line was purchased from Signosis, and the Ramos and Raji cell lines were purchased from ATCC.