Koristka, Stefanie
Ziller-Walter, Pauline
Bergmann, Ralf
Arndt, Claudia
Feldmann, Anja
Kegler, Alexandra
Cartellieri, Marc
Ehninger, Armin
Ehninger, Gerhard
Bornhäuser, Martin
Bachmann, Michael P. http://orcid.org/0000-0002-8029-5755
Funding for this research was provided by:
Bundesministerium für Bildung und Forschung
Article History
Received: 1 September 2018
Accepted: 7 August 2019
First Online: 14 August 2019
Compliance with ethical standards
:
: Michael P. Bachmann is the inventor of the UniCAR platform and, together with Armin Ehninger and Gerhard Ehninger, is a shareholder of the company GEMoaB which holds licenses, patents, and has filed patent applications related to the UniCAR platform. Michael P. Bachmann and Armin Ehninger hold patents related to anti-La mAbs and the La epitopes used in this paper. Marc Cartellieri is an employee of Cellex PT. The remaining authors declare no conflict of interest.
: The work regarding human T cells was approved by the local ethics committee of the university hospital of the Medical Faculty `Carl Gustav Carus’, Technische Universität Dresden (EK27022006). Animal experiments were performed at the Helmholtz-Zentrum Dresden-Rossendorf in accordance with the guidelines of German Regulations of Animal Welfare. The animal study has been approved by the local authorities (Landesdirektion Dresden, 24-9165.40-4, 24.9168.21e4/2004-1). This article does not contain studies with human participants by any of the authors.
: Buffy coats from healthy donors were supplied by the German Red Cross (Dresden, Germany) with written informed consent to use the blood for research purposes.
: All mice used for this study were purchased from Janvier Labs, St. Berthevin, France.
: HEK293T (CRL-11268), PC3 (CRL-1435), 3T3 (CRL-1658), and CHO (CCL-61) cells were obtained from the American Type Culture Collection. As they were recently bought, no further authentication was performed.