Funding for this research was provided by:
Centre hospitalier universitaire Rennes (2015)
Text and Data Mining valid from 2020-01-09
Received: 14 November 2018
Accepted: 26 December 2019
First Online: 9 January 2020
Compliance with ethical standards
: Jonathan M. Irish was a co-founder and was a board member of Cytobank Inc. and received research support from Incyte Corp, Janssen, and Pharmacyclics. The authors declare that there are no other conflicts of interest.
: Sample collection was performed in France (Rennes [all samples except HL #1, #2, #3, and #4] and through the CeVi_collection [HL #1, #2, #3, and #4]). CyTOF analysis was performed in Nashville, TN, USA by Mikael Roussel during a postdoctoral position in Jonathan Irish’s Lab at Vanderbilt University. Data analysis were performed in both sites (Rennes and Nashville). Multiplex IHC was performed in Toulouse (France).
: Samples were obtained under French legal guidelines and fulfilled the requirements of the University Hospital of Rennes institutional ethics committee for samples collected in Rennes (CRB) [approval number DC-2008-630 and DC-2016-2565] and of the Comité de Protection des Personnes for samples collected through the Cevi collection [approval number DC-2013-1783].
: Tissue from patients was acquired with informed consent in accordance with local institutional review and the Declaration of Helsinki. A written consent was obtained from patients before qualification for research in the CRB or the CeVI collection. The consent was for the use of their specimens and data for research and for publication.