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Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis

Published Online: 2021-01-28

Published Print: 2021-08

Authors

Traxel, Sabrina https://orcid.org/0000-0002-9193-5586
Lehmann, Julia https://orcid.org/0000-0003-3717-7603
Richard, Stefanie

Sidorov, Semjon https://orcid.org/0000-0001-5300-664X
Niggli, Felix https://orcid.org/0000-0002-7553-3712
Berger, Christoph https://orcid.org/0000-0002-2373-8804
Nadal, David https://orcid.org/0000-0003-2712-1374
Bürgler, Simone https://orcid.org/0000-0003-3238-5120
Funding

Funding for this research was provided by:

Krebsliga Schweiz (KFS-3958-08-2016-R)

Heidi Ras Stiftung

Children’s Research Center (CRC) of the Children’s Hospital Zurich

Universität Zürich
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Text and Data Mining valid from 2021-01-28

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Article History

Received: 25 May 2020

Accepted: 17 December 2020

First Online: 28 January 2021

Compliance with ethical standards

:

: The authors declare that they have no conflict of interest.

: The study was performed in accordance with the 1964 Declaration of Helsinki. The use of bone marrow mononuclear cells from leukemia patients and palatine tonsils from children undergoing routine tonsillectomy was approved by the regional ethics committee (Kantonale Ethikkommision Zürich, KEK-ZH Nr. StV 40/05 and KEK-ZH Nr. 2014- 0701).

: The guardians of all subjects gave informed consent for the use of samples.

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