Russano, Marco https://orcid.org/0000-0002-6963-3864
Cortellini, Alessio https://orcid.org/0000-0002-1209-5735
Giusti, Raffaele https://orcid.org/0000-0003-4592-8868
Russo, Alessandro https://orcid.org/0000-0002-3365-1972
Zoratto, Federica
Rastelli, Francesca
Gelibter, Alain
Chiari, Rita
Nigro, Olga https://orcid.org/0000-0002-1030-2809
De Tursi, Michele https://orcid.org/0000-0002-1411-1946
Bracarda, Sergio
Gori, Stefania https://orcid.org/0000-0001-6320-405X
Grossi, Francesco https://orcid.org/0000-0001-8412-3136
Bersanelli, Melissa https://orcid.org/0000-0002-6527-6281
Calvetti, Lorenzo https://orcid.org/0000-0002-9135-8715
Di Noia, Vincenzo https://orcid.org/0000-0003-2009-5791
Scartozzi, Mario https://orcid.org/0000-0001-5977-5546
Di Maio, Massimo https://orcid.org/0000-0001-8906-3785
Bossi, Paolo https://orcid.org/0000-0003-0135-0224
Falcone, Alfredo https://orcid.org/0000-0001-5840-2529
Citarella, Fabrizio https://orcid.org/0000-0003-3096-4452
Pantano, Francesco https://orcid.org/0000-0002-2894-9686
Ficorella, Corrado
Filetti, Marco https://orcid.org/0000-0002-4734-7541
Adamo, Vincenzo https://orcid.org/0000-0003-2074-2418
Veltri, Enzo
Pergolesi, Federica
Occhipinti, Mario Alberto https://orcid.org/0000-0002-7169-5343
Nicolardi, Linda
Tuzi, Alessandro
Di Marino, Pietro
Macrini, Serena
Inno, Alessandro https://orcid.org/0000-0001-6331-6908
Ghidini, Michele https://orcid.org/0000-0001-5435-1218
Buti, Sebastiano https://orcid.org/0000-0003-0876-0226
Aprile, Giuseppe
Lai, Eleonora https://orcid.org/0000-0002-0275-8187
Audisio, Marco
Intagliata, Salvatore
Marconcini, Riccardo https://orcid.org/0000-0001-5120-911X
Brocco, Davide
Porzio, Giampiero https://orcid.org/0000-0002-9875-9220
Piras, Marta
Rijavec, Erika
Simionato, Francesca
Natoli, Clara https://orcid.org/0000-0001-7295-0230
Tiseo, Marcello https://orcid.org/0000-0002-9553-8465
Vincenzi, Bruno https://orcid.org/0000-0001-8222-9025
Tonini, Giuseppe https://orcid.org/0000-0003-4442-8677
Santini, Daniele https://orcid.org/0000-0002-9118-3337
Article History
Received: 6 July 2021
Accepted: 23 August 2021
First Online: 31 August 2021
Declarations
:
: Alessio Cortellini received speaker fees and grant consultancies from Roche, MSD, BMS, AstraZeneca, Novartis, Astellas. Marco Russano received honoraria for consultancy and scientific talks from Roche, BMS, MSD, Boehringer Ingelheim, AstraZeneca. Daniele Santini received speaker fees and grant consultancies from Janssen, Astellas, BMS, MSD, Pfizer, Boeringher Ingelheim, Roche, Eisai, Incyte, Novartis. Marcello Tiseo received speakers’ and consultants’ fee from AstraZeneca, Pfizer, Eli-Lilly, BMS, Novartis, Roche, MSD, Boehringer Ingelheim, Otsuka, Takeda, Pierre Fabre. Marcello Tiseo received institutional research grants from AstraZeneca, Boehringer Ingelheim. Sebastiano Buti received honoraria as a speaker at scientific events and advisory role by Bristol-Myers Squibb (BMS), Pfizer; MSD, Ipsen, Roche, Eli-Lilly, AstraZeneca, Pierre Fabre and Novartis.
: The study was approved by the respective local ethical committees on human experimentation of each institution, after previous approval by the coordinating center. The procedures followed were in accordance with the precepts of Good Clinical Practice and the declaration of Helsinki. IRB reference for the control cohort: University of L’Aquila, Internal Review Board protocol number 32865, approved on July 24th, 2018. IRB reference for the LTD cohort: Campus Bio-medico University of Rome, protocol number 37/19 OSS approved on July 24th, 2019.
: All patients alive at the time of data collection provided an informed consent for the present retrospective analysis.
: The authors affirm that human research participants provided informed consent for publication of the images.