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Authors
Kawaguchi, Sho
Kawahara, Kenta https://orcid.org/0000-0002-1407-4866
Fujiwara, Yukio
Ohnishi, Koji
Pan, Cheng
Yano, Hiromu
Hirosue, Akiyuki
Nagata, Masashi
Hirayama, Masatoshi
Sakata, Junki
Nakashima, Hikaru
Arita, Hidetaka
Yamana, Keisuke
Gohara, Shunsuke
Nagao, Yuka
Maeshiro, Manabu
Iwamoto, Asuka
Hirayama, Mayumi
Yoshida, Ryoji
Komohara, Yoshihiro
Nakayama, Hideki
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (JP17K11878, JP20K18699)
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Article History
Received: 16 August 2021
Accepted: 27 December 2021
First Online: 19 January 2022
Declarations
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: The authors declare no competing interests.
: The study was conducted with the approval of the Ethics Committee of Kumamoto University (approval no. RINRI:1427) and in accordance with the guidelines for Good Clinical Practice and the Declaration of Helsinki. The present study was a retrospective analysis, which does not require individual consent; however, all participants had the opportunity to opt out (RINRI1427). All animal experiments were approved by the Ethics Committee for Animal Experiments of Kumamoto University (A2020-068) and performed in accordance with the guidelines for animal experiments in the laboratories. Endpoints were considered, such as euthanasia, at the appropriate time if the animals had intolerable pain (gait disturbance, water/feeding impairment, tumor diameter 20 mm or more, tumor volume 4000 mm<sup>3</sup> or more, and 25% or more weight loss in 7 days).
