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Article History

Received: 6 April 2021

Accepted: 19 January 2022

First Online: 9 March 2022

Declarations

:

: DAM reports serving as a consultant or advisor for Bayer, Boehringer Ingelheim, Clarity Pharmaceuticals, Roche, and Y-mAbs Therapeutics; is a member of a speakers bureau for EUSA Pharma; has received institutional research funding from Bristol Myers Squibb; and has received reimbursement for travel and accommodation expenses from EUSA Pharma and Y-mAbs Therapeutics. KN has received honoraria from and reports serving as a consultant or advisor for Bayer and Y-mAbs Therapeutics. MEM reports serving as a consultant or advisor for Ventana Medical Systems; has received institutional research funding from Bayer, Ignyta, Lilly, MSD, and Roche; holds stock in GE Healthcare, Johnson & Johnson, Teva Pharmaceuticals, and Varian Medical Systems; and has a patent for non-invasive methods of leukaemia cell detection with magnetic resonance imaging/magnetic resonance spectroscopy (US patent 8,894,975). JX was employed by EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA at the time of manuscript preparation. PP and IJ report employment with Merck Healthcare KGaA, Darmstadt, Germany. YV reports employment with EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA. MR reports employment with EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA at the time of manuscript preparation, and holds stock in Bristol Myers Squibb. All other authors declare no competing interests.

: The trial was conducted in accordance with the ethics principles of the Declaration of Helsinki and the International Council for Harmonisation Guideline for Good Clinical Practice. The protocol was approved by the institutional review board or independent ethics committee of each centre. All patients or legal representatives of patients provided written informed consent before enrolment.