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Authors
Wang, Yuedi
Gao, Yiyuan
Niu, Congyi
Wang, Bo
Zhao, Shushu
Roex, Gils
Qian, Jiawen
Qie, Jingbo
Chen, Lin
Yi, Chenhe
Anguille, Sébastien
Liu, Jie
Luo, Feifei
Chu, Yiwei https://orcid.org/0000-0002-5035-1111
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82130050)
National Natural Science Foundation of China (81870375)
National Natural Science Foundation of China (82121002)
Shanghai Rising-Star Program (18QA1401000)
Open Research Fund of State Key Laboratory of Genetic Engineering, Fudan University (SKLGE1911)
Shenzhen Institute of Synthetic Biology Scientific Research Program (ZTXM20214002)
Senior Clinical Investigator of the Research Fund-Flanders (FWO)
Doctoral Grant Strategic Basic Research of the FWO (Grant 1S72821N)
MeToYou Foundation
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Article History
Received: 20 December 2021
Accepted: 24 March 2022
First Online: 19 April 2022
Declarations
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: The authors have no relevant financial or non-financial interests to disclose.
: Human N87, Huh7, Ramos and K562 cell lines were purchased from the Institute of Biochemistry and Cell Biology of the Chinese Academy of Science (Shanghai, China). Human peripheral blood mononuclear cells isolated from healthy donors or patients with hepatocellular carcinoma (HCC) were purchased from the Shanghai Blood Center (Shanghai, China), or obtained from Huashan hospital (Shanghai, China), respectively. Fresh human HCC samples were obtained from surgery performed at the Huashan hospital. Informed consent was obtained from HCC patients involved, and the project was approved by the Ethical Committee of Medical Research, Huashan Hospital of Fudan University (No. 2013-005). Six- to eight-week-old female nude mice (BALB/c) were purchased from SLAC (Shanghai, China) and kept under specific pathogen-free conditions in animal facility of Fudan University. The animal experimental protocol was approved by the Ethics Committee of Fudan University (201901003Z) following the Guidelines for the Care and Use of Laboratory Animals (No. 55 issued by Ministry of Health, China on January 25th, 1998).
