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Authors
Komatsuda, Hiroki
Nagato, Toshihiro
Kosaka, Akemi
Ohkuri, Takayuki
Sasaki, Takaaki
Kumai, Takumi
Kono, Michihisa
Yamaki, Hidekiyo
Wakisaka, Risa
Yasuda, Shunsuke
Inoue, Takahiro
Hayashi, Ryusuke
Ujiie, Nanami
Sato, Ryosuke
Ohara, Kenzo
Kishibe, Kan
Hayashi, Tatsuya
Takahara, Miki
Kobayashi, Hiroya
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (22K09659, 24K12690, 23K24100)
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Article History
Received: 18 March 2025
Accepted: 4 June 2025
First Online: 25 June 2025
Declarations
:
: The authors declare no competing interests.
: This study was performed in compliance with the principles of the Declaration of Helsinki and subsequent amendments, and the study protocol was approved by the Institutional Review Board of the Asahikawa Medical University (#15005 and #16217). All animal experiments were approved by the Institutional Animal Care and Use Committee of Asahikawa Medical University (R6-035).
: As this was a retrospective study using existing specimens and clinical information, the Institutional Review Board approved a waiver of the standard informed consent process for IHC analyses. Instead, an opt-out approach was implemented through the Asahikawa Medical University website that ensured patients retained the right to decline participation in the study. All patients from whom PBMCs were collected received a written explanation of the study and provided written informed consent before participation.
