Document is current
Any future updates will be listed below
-
Authors
Saito, Masato
Kunieda, Kana
Ishii, Toshihiko
Koshiba, Shoko
Ohashi, Rui
Kanda, Yutaka
Yamada, Takuji
- License Information
-
More Information
Article History
Received: 30 June 2025
Accepted: 3 November 2025
First Online: 19 December 2025
Declarations
:
: M.S., K.K., S.K., T.I., R.O., and Y.K. are employees of Kyowa Kirin Co., Ltd. T.Y. is a founder of Metagen Inc., Metagen Therapeutics Inc., and digzyme Inc. Metagen Inc. focuses on the design and control of the gut environment for human health. Metagen Therapeutics Inc. focuses on drug discovery and development which utilizes microbiome science. All of the companies had no control over the interpretation, writing, or publication of this work. The terms of these arrangements are being managed by the Institute of Science Tokyo in accordance with its conflict of interest policies.
: All animal studies were performed in accordance with the Standards for Proper Conduct of Animal Experiments at Kyowa Kirin under the approval of the company’s Institutional Animal Care and Use Committee. Kyowa Kirin is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care, International.
