Changoer, Prashant https://orcid.org/0009-0004-5892-8706
Peng, Chunying https://orcid.org/0000-0001-6726-6581
van Houten, Pepijn https://orcid.org/0000-0002-8503-4140
van Emst, Liesbeth
Walraven, Janneke E. W. https://orcid.org/0000-0001-7161-5369
Ottevanger, Petronella B. https://orcid.org/0000-0001-8209-487X
Jaeger, Martin https://orcid.org/0000-0001-6994-493X
Netea-Maier, Romana T. https://orcid.org/0000-0002-9603-0460
Funding for this research was provided by:
Eisai Europe
Article History
Received: 10 October 2025
Accepted: 15 November 2025
First Online: 19 December 2025
Declarations
:
: The authors declare no conflict of interest.
: The study was approved by the local Ethics Committee (Commissie Mensgebonden Onderzoek Arnhem-Nijmegen: 2020-7123 for longitudinal patients, 2022-16025 for cross-sectional patients, NL84281.091.23 for healthy donors). All donors provided written informed consent, and all study procedures were conducted according to the principles of the Declaration of Helsinki.