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Enhanced antitumor efficacy of combined targeting of adenosine A2B receptor and PD-1 is mediated via multiple effects on different cell populations within tumor microenvironment

Crossref DOI link: https://doi.org/10.1007/s00262-026-04330-1

Published Online: 2026-02-28

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Guan, Shuxiao

Wang, Cankun

Amann, Joseph M.

Cho, Ju Hwan

Ma, Qin

Carbone, David P.
Funding

Funding for this research was provided by:

National Institutes of Health (R01CA248741)
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Text and Data Mining valid from 2026-02-28

Version of Record valid from 2026-02-28
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Article History

Received: 7 November 2025

Accepted: 1 February 2026

First Online: 28 February 2026

Declarations

:

: The authors declare no competing interests.

: All animal work was done with Institutional Animal Care and Use Committee (IACUC) approval of The Ohio State University, following the established guidelines, ID#:2013A00000131-R3.

: All authors have agreed to publication.

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