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Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells

Crossref DOI link: https://doi.org/10.1007/s00266-025-05284-y

Published Online: 2025-10-16

Published Print: 2026-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Jafarzadeh, Alireza https://orcid.org/0000-0001-5878-9778
Hoseini, Seyed Soheil https://orcid.org/0009-0001-0155-7439
Behrangi, Elham https://orcid.org/0000-0002-6545-3460
Roohaninasab, Masoumeh https://orcid.org/0000-0002-2862-6422
Goodarzi, Azadeh https://orcid.org/0000-0002-1249-4429
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Text and Data Mining valid from 2025-10-16

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Article History

Received: 7 May 2025

Accepted: 16 September 2025

First Online: 16 October 2025

Declarations

:

: The authors declare that they have no conflict of interest to disclose.

: All collected data were kept confidential and analyzed without attaching specific names. The study adhered to the ethical principles outlined in the Helsinki Declaration. The project was registered at Iran University of Medical Sciences under registration number IR.IUMS.SM8618222474901L1, with the scientific title "Regenerative Medicine for Atrophic Scars: A Systematic Review of Extracellular Vesicles, Conditioned Media, Stromal Vascular Fraction, and Mesenchymal Stem Cells." It was approved by the Research Council of Iran University of Medical Sciences under the ethics code number IR.IUMS.FMD.REC.1403.911 on September 1, 2024.The authors obtained consent to publish. The current manuscript contains no individual person’s data. Therefore, consent to publish is not applicable.

: For this type of study, informed consent is not required.

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