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A Prospective, Randomized, Active-Controlled, Evaluator-Blinded, Noninferiority Clinical Trial Examining a Non-Cross-Linked Bovine-Derived Type I/III Collagen Filler Combined with Hyaluronic Acid for Periocular Rejuvenation

Crossref DOI link: https://doi.org/10.1007/s00266-025-05499-z

Published Online: 2025-12-04

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhu, Guo-Sheng

Zhang, Si-Yi

Deng, Lu-Wen

Yang, Fang

Wang, Xiang

Wang, Hong-Yan

Li, Hong-Qiang

Hong, Wei-Jin

Luo, Sheng-Kang https://orcid.org/0000-0002-5123-1656
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Article History

Received: 30 July 2025

Accepted: 20 November 2025

First Online: 4 December 2025

Declarations

:

: The authors declare that they have no conflicts of interest to disclose.

: The study protocol was approved by the Institutional Review Board of the Hospital.

: All patients provided written informed consent.

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