Cornelissen, Loes L. http://orcid.org/0000-0003-1813-8780
Kreuger, Aukje L. http://orcid.org/0000-0002-1658-9257
Caram-Deelder, Camila http://orcid.org/0000-0003-3161-5684
Middelburg, Rutger A. http://orcid.org/0000-0002-6545-7277
Kerkhoffs, Jean Louis H.
von dem Borne, Peter A.
Beckers, Erik A. M.
de Vooght, Karen M. K.
Kuball, Jürgen
Zwaginga, J. J. http://orcid.org/0000-0003-1228-7769
van der Bom, Johanna G. http://orcid.org/0000-0001-9095-2475
Funding for this research was provided by:
Stichting Sanquin Bloedvoorziening (PPOC-12-028 PRG)
Article History
Received: 28 July 2020
Accepted: 3 October 2020
First Online: 17 October 2020
Compliance with ethical standards
: This observational study used only routinely reported data. Data was collected by researchers who are trained medical doctors. There were no additional risks for the patients and all data was pseudonymized before analyses. The medical ethical committee of the LUMC judged the study not to meet the criteria for the Medical Research Involving Human Subjects Act (Dutch: Wet Medisch Wetenschappelijk Onderzoek met Mensen). Furthermore, the majority of patients were expected to be deceased. Obtaining an informed consent (from patients or relatives) was thought to be a larger burden and invasion of privacy than performing the study, with the available data, without informing the patients or their relatives. The need for informed consent was therefore waived by the ethical committee.
: J.L.K. receives a research subsidy from TerumoBCT. J.K. is a scientific cofounder and shareholder of Gadeta and is an inventor on multiple patents on gdTCRs, gdTCR ligands, and isolation strategies. J.K. receives research support from Gadeta, Miltenyi Biotech, and Novartis. J.J.Z. is in the scientific advisory council of Novartis/Amgen/Sanofi and received a speaker’s fee; he also received a speaker’s fee from Vifor Pharma. The other authors declare no disclosures.