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Article History

Received: 19 February 2025

Accepted: 28 April 2025

First Online: 19 September 2025

Declarations

:

: Written informed consent was obtained from the patient’s family to publish this case report. No personal details that can identify the patient were included in the submission.

: Written informed consent was obtained from the patient’s family to publish this case report. No personal details that could identify the patient were included in the submission.

: The authors declare no competing interests.

: This study reports a rare case of simultaneous T-cell antigen expression and monoclonal TCR gene rearrangement in PEL, a phenomenon rarely discussed in the existing literature. It provides a concise overview of other instances of lineage infidelity, with a particular focus on EBV and other potential underlying causes. This report provides valuable insights for both diagnostic and clinical research. Presenting a case of lymphoma with mixed immunophenotypic and genetic features highlights the challenges in diagnosing hematologic malignancies and expands the understanding of the relationship between EBV and gene regulation mechanisms. These findings are likely to attract significant interest from hematologists, oncologists, and molecular pathologists studying hematologic malignancies involving lineage infidelity.