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Article History

Received: 9 April 2025

Accepted: 10 June 2025

First Online: 12 July 2025

Declarations

:

: The study was approved by the Ethics Committee of the Hospital Clínic de Barcelona and conducted following standards set forth by the Declaration of HelsinkiThe study was approved by the Ethics Committee of the Hospital Clínic de Barcelona and conducted following standards set forth by the Declaration of Helsinki.

: All patients provided their informed consent for the use of laboratory results and genetic analyses.

: CJV serves as educational speaker for AbbVie and Pfizer and received travel grants from AbbVie, Jazz Pharmaceuticals and Pfizer. MDB serves as a consultant for, in an advisory role for, received travel grants from, or served as speaker for BMS, AbbVie, Astellas, JazzPharma, Takeda, and Novartis. JE declares consultancy honoraria from AbbVie, Novartis, Astellas, Jazz Pharmaceuticals, BMS-Celgene, Pfizer, and Daichii-Sankyo, and received research grants from Novartis, Jazz Pharmaceuticals, and Pfizer. The remaining authors declare no competing financial interests. The founders had no role in the design of the study; in the collection, analyses or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results.