Yoshino, Takayuki
Kotaka, Masahito
Shinozaki, Katsunori
Touyama, Tetsuo
Manaka, Dai
Matsui, Takanori
Ishigure, Kiyoshi
Hasegawa, Junichi
Inoue, Keiji
Munemoto, Yoshinori
Takagane, Akinori
Ishikawa, Hiroshi
Ishida, Hideyuki
Ogata, Yutaka
Oba, Koji
Goto, Koichi
Sakamoto, Junichi
Maehara, Yoshihiko
Ohtsu, Atsushi
Article History
Received: 26 April 2019
Accepted: 4 September 2019
First Online: 23 September 2019
Compliance with ethical standards
:
: T. Yoshino has received grants from MSD K.K., Sanofi K.K., Sumitomo Dainippon Pharma Co., Ltd., Chugai Pharmaceutical Co., Ltd., GlaxoSmithKline K.K., and Nippon Boehringer Ingelheim Co., Ltd., and honoraria from Sanofi K.K., Chugai Pharmaceutical Co., Ltd., Eli Lilly Japan K.K, and Merck Serono Co., Ltd. outside the submitted work; M. Kotaka has received honoraria from Chugai Pharmaceutical Co., Ltd., Yakult Honsha Co., Ltd., Takeda Pharmaceutical Co., Ltd., Merck Serono Co., Ltd., and Taiho Pharmaceutical Co., Ltd. outside the submitted work; K. Shinozaki has received honoraria from Chugai Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., Merck Serono Co., Ltd., Taiho Pharmaceutical Co., Ltd., Yakult Honsha Co., Ltd., Astellas Pharma Inc., Novartis Pharma K.K., Eisai Co., Ltd., Eli Lilly Japan K.K., Shionogi & Co., Ltd., Kyowa Hakko Kirin Co., Ltd., and Asahi Kasei Pharma Co. outside the submitted work; T. Touyama declares no conflicts of interest; D. Manaka declares no conflicts of interest; T. Matsui declares no conflicts of interest; K. Ishigure has received honoraria from ONO Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., and Yakult Honsha Co., Ltd. outside the submitted work; J. Hasegawa declares no conflicts of interest; K. Inoue declares no conflicts of interest; Y. Munemoto declares no conflicts of interest; A. Takagane declares no conflicts of interest; H. Ishikawa declares no conflicts of interest; H. Ishida has received personal fees from Asahi Kasei, Takeda Pharmaceutical Co., Ltd., and Chugai Pharmaceutical Co., Ltd. outside the submitted work; Y. Ogata declares no conflicts of interest; K. Oba has received personal fees from Eisai Co., Ltd., Bristol-Myers Squibb K.K., Merck Serono Japan, ONO Pharmaceutical Co., Ltd., Asahi Kasei, Takeda Pharmaceutical Co., Ltd., Daiichi Sankyo, Inc. and Chugai Pharmaceutical Co., Ltd. outside the submitted work; K. Goto has received grants and personal fees from Stemcentrx (now part of AbbVie), AstraZeneca K.K., Boehringer Ingelheim, Bristol-Myers Squibb K.K., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo, Inc., Eli Lilly Japan K.K., Life Technologies Japan Ltd., Merck Serono Co., Ltd., MSD K.K., Novartis Pharma K.K., ONO Pharmaceutical Co., Ltd., Pfizer Japan Inc., Riken Genesis Co., Ltd., Taiho Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd., grants from Amgen Astellas BioPharma K.K., Astellas Pharma Inc., Eisai Co., Ltd., Ignyta Inc., Janssen Pharmaceutical K.K., Kyowa Hakko Kirin Co., Ltd., Loxo Oncology, Inc., Oxonc, RTI Health Solutions, Sumitomo Dainippon Pharma Co., Ltd., as well as personal fees from F. Hoffmann-La Roche Ltd., Nippon Kayaku Co., Ltd., Otsuka Pharmaceutical Co., Ltd., and SRL Inc. outside the submitted work; J. Sakamoto has received consultant fees from Takeda Pharmaceutical Co., Ltd., honoraria from Tsumura Co., Ltd., Nippon Kayaku Co., Ltd., and Chugai Pharmaceutical Co., Ltd. outside the submitted work; Y. Maehara has received grants from Yakult Honsha Co., Ltd. outside the submitted work; A. Ohtsu has received grants and personal fees from Bristol-Myers Squibb K.K., personal fees from ONO Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., and Taiho Pharmaceutical Co., Ltd. outside the submitted work.
: The institutional review board at each study center approved the protocol, and the study was conducted by the Japanese Foundation for Multidisciplinary Treatment of Cancer (JFMC), a non-commercial organization for investigator-initiated cancer trials, in accordance with the principles expressed in the Declaration of Helsinki. All patients provided written informed consent prior to enrolment. This study is registered with UMIN Clinical Trial Registry (Trial Identifier UMIN000004443).